Cargando…

Nose to brain delivery of Efavirenz nanosuspension for effective neuro AIDS therapy: in-vitro, in-vivo and pharmacokinetic assessment

Efavirenz is inhibitor of non-nucleoside reverse transcriptase enzyme; BCS class II drug. The objective of the present research was to prepare and evaluate nanosuspension of Efavirenz for the treatment of neuro-AIDS. Efavirenz is the substrate for drug resistant proteins at BBB prone to efflux and c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kakad, Smita, Kshirsagar, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637478/ https://www.ncbi.nlm.nih.gov/pubmed/34901485 http://dx.doi.org/10.1016/j.heliyon.2021.e08368

Ejemplares similares

Nose to brain delivery of nanosuspensions with first line antiviral agents is alternative treatment option to Neuro-AIDS treatment
por: Kakad, Smita P., et al.
Publicado: (2022)

Nose-to-Brain Delivery by Nanosuspensions-Based in situ Gel for Breviscapine
por: Chen, Yingchong, et al.
Publicado: (2020)

Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS
por: Sarma, Anupam, et al.
Publicado: (2020)

The effect of surface treatment on the brain delivery of curcumin nanosuspension: in vitro and in vivo studies
por: Dibaei, Maryam, et al.
Publicado: (2019)

Formulation and pharmacokinetic evaluation of a paclitaxel nanosuspension for intravenous delivery
por: Wang, Yonglu, et al.
Publicado: (2011)

The Impact of Process and Formulation Parameters on the Fabrication of Efavirenz Nanosuspension to Improve Drug Solubility and Dissolution
por: Rashed, Mahtab, et al.
Publicado: (2022)

Influence of Stabilizer on the Development of Luteolin Nanosuspension for Cutaneous Delivery: An In Vitro and In Vivo Evaluation
por: Elmowafy, Mohammed, et al.
Publicado: (2021)

Preparation, characterization and pharmacokinetics of cyadox nanosuspension
por: Sattar, Adeel, et al.
Publicado: (2017)

Pharmacokinetics and Anti-Diabetic Studies of Gliclazide Nanosuspension
por: Sampathi, Sunitha, et al.
Publicado: (2022)

Computational, In Vitro, and In Vivo Models for Nose-to-Brain Drug Delivery Studies
por: Boyuklieva, Radka, et al.
Publicado: (2023)

Solid lipid nanoparticles for nose to brain delivery of haloperidol: in vitro drug release and pharmacokinetics evaluation
por: Yasir, Mohd, et al.
Publicado: (2014)

Preparation and Pharmacokinetic Characterization of an Anti-Virulence Compound Nanosuspensions
por: Wang, Nan, et al.
Publicado: (2021)

Therapeutic Potential of Naringenin Nanosuspension: In Vitro and In Vivo Anti-Osteoporotic Studies
por: Gera, Sonia, et al.
Publicado: (2022)

Potential therapeutic effects of naringin loaded PLGA nanoparticles for the management of Alzheimer's disease: In vitro, ex vivo and in vivo investigation
por: Dashputre, Neelam L., et al.
Publicado: (2023)

Itraconazole nanosuspension for oral delivery: Formulation, characterization and in vitro comparison with marketed formulation
por: Nakarani, M., et al.
Publicado: (2010)

Emerging role of nanosuspensions in drug delivery systems
por: Jacob, Shery, et al.
Publicado: (2020)

Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: Characterization, neuroprotective effect and in vivo pharmacokinetic study
por: Li, Linghui, et al.
Publicado: (2023)

Sustained delivery of a camptothecin prodrug – CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity
por: Dong, Dong, et al.
Publicado: (2019)

Effect of particle size on oral absorption of carvedilol nanosuspensions: in vitro and in vivo evaluation
por: Liu, Dandan, et al.
Publicado: (2015)

Optimization of Extended-Release ZL-004 Nanosuspensions for In Vivo Pharmacokinetic Study to Enhance Low Solubility and Compliance
por: Guo, Chengyue, et al.
Publicado: (2018)

Nose-to-Brain Delivery
por: Giunchedi, Paolo, et al.
Publicado: (2020)

Nanosuspension Technology: Recent Patents on Drug Delivery and their Characterizations
por: Goel, Surya, et al.
Publicado: (2019)

Deferasirox Nanosuspension Loaded Dissolving Microneedles for Intradermal Delivery
por: Faizi, Hafsa Shahid, et al.
Publicado: (2022)

Preparation and In Vitro/Ex Vivo Evaluation of Moxifloxacin-Loaded PLGA Nanosuspensions for Ophthalmic Application
por: Mudgil, Meetali, et al.
Publicado: (2013)

Evaluation of Aerosol Delivery of Nanosuspension for Pre-clinical Pulmonary Drug Delivery
por: Chiang, Po-Chang, et al.
Publicado: (2009)

Nose to Brain Delivery of Phenytoin Sodium Loaded Nano Lipid Carriers: Formulation, Drug Release, Permeation and In Vivo Pharmacokinetic Studies
por: Nair, Sreeja C., et al.
Publicado: (2021)

Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery
por: Kannavou, Maria, et al.
Publicado: (2023)

The impact of genetic polymorphisms on the pharmacokinetics of efavirenz in African children
por: Bienczak, Andrzej, et al.
Publicado: (2016)

In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates
por: Giuliani, Alessandro, et al.
Publicado: (2018)

Preparation of high drug-loading celastrol nanosuspensions and their anti-breast cancer activities in vitro and in vivo
por: Huang, Tiantian, et al.
Publicado: (2020)

Formulation and evaluation of docetaxel nanosuspensions: In-vitro evaluation and cytotoxicity
por: Ibrahim, Mohamed A., et al.
Publicado: (2019)

Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin
por: Abdelghany, Sharif, et al.
Publicado: (2019)

Pharmacokinetic evaluation of a 1,3-dicyclohexylurea nanosuspension formulation to support early efficacy assessment
por: Wahlstrom, Jan L, et al.
Publicado: (2007)

Enhanced Oral Bioavailability of Efavirenz by Solid Lipid Nanoparticles: In Vitro Drug Release and Pharmacokinetics Studies
por: Gaur, Praveen Kumar, et al.
Publicado: (2014)

Pharmacokinetics and Pharmacodynamics of Intranasal Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Nose-to-Brain Delivery
por: Nguyen, Thi-Thao-Linh, et al.
Publicado: (2022)

Optimization of Bromocriptine-Mesylate-Loaded Polycaprolactone Nanoparticles Coated with Chitosan for Nose-to-Brain Delivery: In Vitro and In Vivo Studies
por: Badran, Mohamed M., et al.
Publicado: (2023)

Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions
por: Li, Haowen, et al.
Publicado: (2021)

High drug payload curcumin nanosuspensions stabilized by mPEG-DSPE and SPC: in vitro and in vivo evaluation
por: Hong, Jingyi, et al.
Publicado: (2017)

Investigation of the “Nose-to-Brain” Pathways in Intranasal HupA Nanoemulsions and Evaluation of Their in vivo Pharmacokinetics and Brain-Targeting Ability
por: Jiang, Yueyao, et al.
Publicado: (2022)

Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen
por: Ramadon, Delly, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tjvddmrjqqoil1e2uf2goj9gcn