ERK signaling controls productive HIF‐1 binding to chromatin and cancer cell adaptation to hypoxia through HIF‐1α interaction with NPM1

The hypoxia‐inducible factor HIF‐1 is essential for oxygen homeostasis. Despite its well‐understood oxygen‐dependent expression, regulation of its transcriptional activity remains unclear. We show that phosphorylation by extracellular signal‐regulated kinases1/2 (ERK1/2), in addition to promoting HI...

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Detalles Bibliográficos
Autores principales: Koukoulas, Kreon, Giakountis, Antonis, Karagiota, Angeliki, Samiotaki, Martina, Panayotou, George, Simos, George, Mylonis, Ilias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637566/
https://www.ncbi.nlm.nih.gov/pubmed/34388291
http://dx.doi.org/10.1002/1878-0261.13080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637566/
https://www.ncbi.nlm.nih.gov/pubmed/34388291
http://dx.doi.org/10.1002/1878-0261.13080

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