Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action

BACKGROUND: Methotrexate (MTX) is the first line treatment of rheumatoid arthritis (RA), and methylation changes in bulk T cells have been reported after treatment with MTX. We have investigated cell-type specific DNA methylation changes across the genome in naïve and memory CD4(+) T cells before an...

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Detalles Bibliográficos
Autores principales: Guderud, Kari, Sunde, Line H., Flåm, Siri T., Mæhlen, Marthe T., Mjaavatten, Maria D., Norli, Ellen S., Evenrød, Ida M., Andreassen, Bettina K., Franzenburg, Sören, Franke, Andre, Rayner, Simon, Gervin, Kristina, Lie, Benedicte A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637827/
https://www.ncbi.nlm.nih.gov/pubmed/34867944
http://dx.doi.org/10.3389/fimmu.2021.713611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637827/
https://www.ncbi.nlm.nih.gov/pubmed/34867944
http://dx.doi.org/10.3389/fimmu.2021.713611

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