Alkyl vs. aryl modifications: a comparative study on modular modifications of triphenylphosphonium mitochondrial vectors

Triphenylphosphonium (TPP(+)) moieties are commonly conjugated to drug molecules to confer mitochondrial selectivity due to their positive charge and high lipophilicity. Although optimisation of lipophilicity can be achieved by modifying the length of the alkyl linkers between the TPP(+) moiety and...

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Detalles Bibliográficos
Autores principales: Ong, How Chee, Coimbra, João T. S., Kwek, Germain, Ramos, Maria J., Xing, Bengang, Fernandes, Pedro A., García, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637833/
https://www.ncbi.nlm.nih.gov/pubmed/34977579
http://dx.doi.org/10.1039/d1cb00099c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637833/
https://www.ncbi.nlm.nih.gov/pubmed/34977579
http://dx.doi.org/10.1039/d1cb00099c

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