Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

The metabolism of l-tryptophan to N-formyl-l-kynurenine by indoleamine-2,3-dioxygenase 1 (IDO1) is thought to play a critical role in tumour-mediated immune suppression. Whilst there has been significant progress in elucidating the overall enzymatic mechanism of IDO1 and related enzymes, key aspects...

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Detalles Bibliográficos
Autores principales: Cundy, Nicholas J., Hare, Roseanna K., Tang, Tina, Leach, Andrew G., Jowitt, Thomas A., Qureshi, Omar, Gordon, John, Barnes, Nicholas M., Brady, Catherine A., Raven, Emma L., Grainger, Richard S., Butterworth, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637876/
https://www.ncbi.nlm.nih.gov/pubmed/34977580
http://dx.doi.org/10.1039/d0cb00209g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637876/
https://www.ncbi.nlm.nih.gov/pubmed/34977580
http://dx.doi.org/10.1039/d0cb00209g

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