Cargando…

Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

The metabolism of l-tryptophan to N-formyl-l-kynurenine by indoleamine-2,3-dioxygenase 1 (IDO1) is thought to play a critical role in tumour-mediated immune suppression. Whilst there has been significant progress in elucidating the overall enzymatic mechanism of IDO1 and related enzymes, key aspects...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cundy, Nicholas J., Hare, Roseanna K., Tang, Tina, Leach, Andrew G., Jowitt, Thomas A., Qureshi, Omar, Gordon, John, Barnes, Nicholas M., Brady, Catherine A., Raven, Emma L., Grainger, Richard S., Butterworth, Sam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8637876/ https://www.ncbi.nlm.nih.gov/pubmed/34977580 http://dx.doi.org/10.1039/d0cb00209g

Ejemplares similares

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan
por: Metz, Richard, et al.
Publicado: (2012)

IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease
por: Sucher, Robert, et al.
Publicado: (2010)

IDO-induced immunosuppressive tryptophan catabolism following primary HIV infection
por: Jenabian, Mohammad-Ali, et al.
Publicado: (2014)

The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells
por: Opitz, Christiane A., et al.
Publicado: (2011)

Synthesis of constrained analogues of tryptophan
por: Rossi, Elisabetta, et al.
Publicado: (2015)

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis
por: Zelante, Teresa, et al.
Publicado: (2014)

Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment
por: Günther, Juliane, et al.
Publicado: (2019)

Heme-binding-mediated negative regulation of the tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) by IDO2
por: Lee, Young-Kwan, et al.
Publicado: (2014)

Activities of plasma indoleamine-2, 3-dioxygenase (IDO) enzyme in Nigerian patients with lung diseases: basis for tryptophan supplementation or IDO inhibitor use
por: Arinola, Ganiyu Olatunbosun, et al.
Publicado: (2023)

Incorporation of tryptophan analogues into the lantibiotic nisin
por: Zhou, Liang, et al.
Publicado: (2016)

The lexicon of antimicrobial peptides: a complete set of arginine and tryptophan sequences
por: Clark, Sam, et al.
Publicado: (2021)

Psychological Stress-Induced, IDO1-Dependent Tryptophan Catabolism: Implications on Immunosuppression in Mice and Humans
por: Kiank, Cornelia, et al.
Publicado: (2010)

Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO
por: Kim, Minah, et al.
Publicado: (2021)

Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma
por: Zhai, Lijie, et al.
Publicado: (2021)

USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer
por: Shi, Dongni, et al.
Publicado: (2022)

The IDO inhibitor 1-methyl tryptophan activates the aryl hydrocarbon receptor response in mesenchymal stromal cells
por: Lewis, Holly C., et al.
Publicado: (2017)

IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer
por: Zeitler, Leonie, et al.
Publicado: (2023)

Electroacupuncture Relieves LPS-Induced Depression-Like Behaviour in Rats Through IDO-Mediated Tryptophan-Degrading Pathway
por: Zhang, Kun, et al.
Publicado: (2020)

Tryptophan Analogues with Fixed Side‐Chain Orientation: Expanding the Scope
por: Nicke, Lennart, et al.
Publicado: (2020)

Exogenous Tryptophan Promotes Cutaneous Wound Healing of Chronically Stressed Mice through Inhibition of TNF-α and IDO Activation
por: Bandeira, Luana Graziella, et al.
Publicado: (2015)

Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells
por: Newman, Alice Clare, et al.
Publicado: (2021)

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis
por: Wei, Chunyan, et al.
Publicado: (2016)

Cang-Ai Volatile Oil Ameliorates Depressive Behavior Induced by Chronic Stress Through IDO-Mediated Tryptophan Degradation Pathway
por: Zhang, Kailing, et al.
Publicado: (2021)

L-Tryptophan Production by Auxotrophic and Analogue Resistant Mutants of Aureobacterium flavescens
por: Roy, A., et al.
Publicado: (2011)

Need to focus on inhibitory activity of benzimidazole analogues against indolamine 2,3-dioxygenase-1 (IDO-1)
por: Sharma, Akshansh, et al.
Publicado: (2022)

Impact of IDO1 and IDO2 on the B Cell Immune Response
por: Merlo, Lauren M. F., et al.
Publicado: (2022)

Tranilast, an analogue of tryptophan catabolites, induces allograft tolerance by CD161(+) cells
por: Ménoret, Séverine, et al.
Publicado: (2011)

A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase
por: Ortmayer, Mary, et al.
Publicado: (2021)

Tryptophan Residues Are Critical for Portal Protein Assembly and Incorporation in Bacteriophage P22
por: Woodbury, Brianna M., et al.
Publicado: (2022)

Differential Roles of IDO1 and IDO2 in T and B Cell Inflammatory Immune Responses
por: Merlo, Lauren M. F., et al.
Publicado: (2020)

Synthesis and characterization of an unnatural boron and nitrogen-containing tryptophan analogue and its incorporation into proteins
por: Boknevitz, Katherine, et al.
Publicado: (2019)

Probing the polarity and water environment at the protein-peptide binding interface using tryptophan analogues
por: Chen, Yi-Ting, et al.
Publicado: (2016)

Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
por: Romney, David K., et al.
Publicado: (2017)

Host cell depletion of tryptophan by IFNγ-induced Indoleamine 2,3-dioxygenase 1 (IDO1) inhibits lysosomal replication of Coxiella burnetii
por: Ganesan, Sandhya, et al.
Publicado: (2019)

Genetic Polymorphisms Affecting IDO1 or IDO2 Activity Differently Associate With Aspergillosis in Humans
por: Napolioni, Valerio, et al.
Publicado: (2019)

Discovery and Characterisation of Dual Inhibitors of Tryptophan 2,3-Dioxygenase (TDO2) and Indoleamine 2,3-Dioxygenase 1 (IDO1) Using Virtual Screening
por: Sari, Suat, et al.
Publicado: (2019)

Side Chain Orientation of Tryptophan Analogues Determines Agonism and Inverse Agonism in Short Ghrelin Peptides
por: Nicke, Lennart, et al.
Publicado: (2019)

PET imaging of medulloblastoma with an (18)F-labeled tryptophan analogue in a transgenic mouse model
por: Xin, Yangchun, et al.
Publicado: (2020)

Aging-associated increase in indoleamine 2,3-dioxygenase (IDO) activity appears to be unrelated to the transcription of the IDO1 or IDO2 genes in peripheral blood mononuclear cells
por: Marttila, Saara, et al.
Publicado: (2011)

Amyloid β neurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor
por: Duan, Zhenzhen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_npjgh23os9ll3rs8vduflbpoo6