Cargando…
Therapeutic implications of cancer gene amplifications without mRNA overexpression: silence may not be golden
Amplifications of oncogenic genes are often considered actionable. However, not all patients respond. Questions have therefore arisen regarding the degree to which amplifications, especially non-focal ones, mediate overexpression. We found that a subset of high-level gene amplifications (≥ 6 copies)...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638100/ https://www.ncbi.nlm.nih.gov/pubmed/34857015 http://dx.doi.org/10.1186/s13045-021-01211-1 |