Cargando…

Rare and potentially pathogenic variants in hydroxycarboxylic acid receptor genes identified in breast cancer cases

BACKGROUND: Three genes clustered together on chromosome 12 comprise a group of hydroxycarboxylic acid receptors (HCARs): HCAR1, HCAR2, and HCAR3. These paralogous genes encode different G-protein coupled receptors responsible for detecting glycolytic metabolites and controlling fatty acid oxidation...

Descripción completa

Detalles Bibliográficos
Autores principales:	McGuire Sams, Cierla, Shepp, Kasey, Pugh, Jada, Bishop, Madison R., Merner, Nancy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638184/ https://www.ncbi.nlm.nih.gov/pubmed/34852802 http://dx.doi.org/10.1186/s12920-021-01126-3

Ejemplares similares

Production of Hydroxycarboxylic Acid Receptor 3 (HCA(3)) Ligands by Bifidobacterium
por: Sakurai, Takuma, et al.
Publicado: (2021)

Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding
por: Suzuki, Shota, et al.
Publicado: (2023)

Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
por: Stäubert, Claudia, et al.
Publicado: (2015)

Natural biased signaling of hydroxycarboxylic acid receptor 3 and G protein-coupled receptor 84
por: Peters, Anna, et al.
Publicado: (2020)

Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion
por: Buscemi, Lara, et al.
Publicado: (2021)

Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2
por: Cheng, Lin, et al.
Publicado: (2023)

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2
por: Pan, Xin, et al.
Publicado: (2023)

Enatiomerically pure hydroxycarboxylic acids: current approaches and future perspectives
por: Ren, Qun, et al.
Publicado: (2010)

Chiroptical activity of hydroxycarboxylic acids with implications for the origin of biological homochirality
por: Bocková, Jana, et al.
Publicado: (2021)

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants
por: Vohra, Rupali, et al.
Publicado: (2022)

Establishment of the Alabama Hereditary Cancer Cohort ‐ strategies for the inclusion of underrepresented populations in cancer genetics research
por: Bishop, Madison R., et al.
Publicado: (2018)

Cover
por: Bishop, Madison R., et al.
Publicado: (2018)

A research-based gene panel to investigate breast, ovarian and prostate cancer genetic risk
por: Bishop, Madison R., et al.
Publicado: (2019)

Gene panel screening for insight towards breast cancer susceptibility in different ethnicities
por: Bishop, Madison R., et al.
Publicado: (2020)

Combining metabolic phenotype determination with metabolomics and transcriptional analyses to reveal pathways regulated by hydroxycarboxylic acid receptor 2
por: Rabe, Philipp, et al.
Publicado: (2022)

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation
por: Wannick, Melanie, et al.
Publicado: (2018)

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA(2))
por: Markovics, Arnold, et al.
Publicado: (2019)

Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
por: Peters, Anna, et al.
Publicado: (2019)

Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors
por: Wellbourne-Wood, Joel, et al.
Publicado: (2022)

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response
por: Parodi, Benedetta, et al.
Publicado: (2021)

Elevated Circulating Lactate Levels and Widespread Expression of Its Cognate Receptor, Hydroxycarboxylic Acid Receptor 1 (HCAR1), in Ovarian Cancer
por: Kerslake, Rachel, et al.
Publicado: (2022)

Correction: Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3
por: Peters, Anna, et al.
Publicado: (2019)

Study on the Hydration of α-Pinene Catalyzed by α-Hydroxycarboxylic Acid–Boric Acid Composite Catalysts
por: Meng, Zhonglei, et al.
Publicado: (2023)

β-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis
por: Carretta, María D., et al.
Publicado: (2020)

Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3‐Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects
por: Gopalasingam, Nigopan, et al.
Publicado: (2023)

Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from L-α-Amino Acids
por: Pickl, Mathias, et al.
Publicado: (2021)

An investigation into the role of inherited CEACAM gene family variants and colorectal cancer risk
por: Huskey, Anna L. W., et al.
Publicado: (2022)

Subverting Toll-Like Receptor Signaling by Bacterial Pathogens
por: McGuire, Victoria A., et al.
Publicado: (2015)

Lower frequency of TLR9 variant associated with protection from breast cancer among African Americans
por: Chandler, Madison R., et al.
Publicado: (2017)

Enantioseparation of 3-Hydroxycarboxylic Acids via Diastereomeric Salt Formation by 2-Amino-1,2-diphenylethanol (ADPE) and Cinchonidine
por: Chandrasekaran, Srinivas, et al.
Publicado: (2022)

Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway
por: Ma, Xiaocao, et al.
Publicado: (2020)

A Fast Association Test for Identifying Pathogenic Variants Involved in Rare Diseases
por: Greene, Daniel, et al.
Publicado: (2017)

A monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humans
por: Goebel, Katie, et al.
Publicado: (2017)

L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation
por: Wagner, Waldemar, et al.
Publicado: (2015)

Anodic oxidation triggered divergent 1,2- and 1,4-group transfer reactions of β-hydroxycarboxylic acids enabled by electrochemical regulation
por: Zhang, Zhenxing, et al.
Publicado: (2020)

Structural Speciation of Ti(IV)-(α-Hydroxycarboxylic Acid) Complexes in Metabolism-Related (Patho)Physiology—In Vitro Approaches to (Pre)Adipocyte Differentiation and Mineralization
por: Tsave, Olga, et al.
Publicado: (2023)

The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A
por: Bisenieks, Egils, et al.
Publicado: (2021)

Rare Germline Pathogenic Variants Identified by Multigene Panel Testing and the Risk of Aggressive Prostate Cancer
por: Nguyen-Dumont, Tú, et al.
Publicado: (2021)

Image models (and their speech model cousins)
por: Levinson, Stephen, et al.
Publicado: (1996)

A rare case of tumor-to-tumor metastasis: breast cancer metastatic to a benign renal mass
por: Diego, Emilia, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_55dbjiogf6kb7m4k19lc59krb5