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Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B

[Image: see text] Methionine adenosyltransferase (MAT) catalyzes the adenosine 5′-triphosphate (ATP) and l-methionine (l-Met) dependent formation of S-adenosyl-l-methionine (SAM), the principal methyl donor of most biological transmethylation reactions. We carried out in-depth kinetic studies to fur...

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Detalles Bibliográficos
Autores principales: Bailey, Jonathan, Douglas, Holly, Masino, Laura, de Carvalho, Luiz Pedro Sorio, Argyrou, Argyrides
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638259/
https://www.ncbi.nlm.nih.gov/pubmed/34780697
http://dx.doi.org/10.1021/acs.biochem.1c00672