Compartment‐specific (13)C metabolic flux analysis reveals boosted NADPH availability coinciding with increased cell‐specific productivity for IgG1 producing CHO cells after MTA treatment

Increasing cell‐specific productivities (CSPs) for the production of heterologous proteins in Chinese hamster ovary (CHO) cells is an omnipresent need in the biopharmaceutical industry. The novel additive 5′‐deoxy‐5′‐(methylthio)adenosine (MTA), a chemical degradation product of S‐(5′‐adenosyl)‐ʟ‐me...

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Detalles Bibliográficos
Autores principales: Wijaya, Andy Wiranata, Verhagen, Natascha, Teleki, Attila, Takors, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638276/
https://www.ncbi.nlm.nih.gov/pubmed/34899120
http://dx.doi.org/10.1002/elsc.202100057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638276/
https://www.ncbi.nlm.nih.gov/pubmed/34899120
http://dx.doi.org/10.1002/elsc.202100057

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