Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains

The G2019S mutation in leucine-rich repeat kinase 2 (LRRK2) causes familial Parkinson’s disease (PD) and is also found in a subset of idiopathic cases. Prior studies in Drosophila and human induced pluripotent stem cell (iPSC)-derived dopamine neurons uncovered a pronounced effect of G2019S LRRK2 on...

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Detalles Bibliográficos
Autores principales: Kim, Jungwoo Wren, Yin, Xiling, Martin, Ian, Xiong, Yulan, Eacker, Stephen M., Ingolia, Nicholas T., Dawson, Ted M., Dawson, Valina L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638676/
https://www.ncbi.nlm.nih.gov/pubmed/34759048
http://dx.doi.org/10.1523/ENEURO.0310-21.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638676/
https://www.ncbi.nlm.nih.gov/pubmed/34759048
http://dx.doi.org/10.1523/ENEURO.0310-21.2021

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