Sustained ErbB Activation Causes Demyelination and Hypomyelination by Driving Necroptosis of Mature Oligodendrocytes and Apoptosis of Oligodendrocyte Precursor Cells

Oligodendrocytes are vulnerable to genetic and environmental insults and its injury leads to demyelinating diseases. The roles of ErbB receptors in maintaining the CNS myelin integrity are largely unknown. Here, we overactivate ErbB receptors that mediate signaling of either neuregulin (NRG) or epid...

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Detalles Bibliográficos
Autores principales: Hu, Xu, Xiao, Guanxiu, He, Li, Niu, Xiaojie, Li, Huashun, Lou, Tianjie, Hu, Qianqian, Yang, Youguang, Xu, Qi, Wei, Zhengdong, Qiu, Mengsheng, Tanaka, Kenji F., Shen, Ying, Tao, Yanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638686/
https://www.ncbi.nlm.nih.gov/pubmed/34725188
http://dx.doi.org/10.1523/JNEUROSCI.2922-20.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638686/
https://www.ncbi.nlm.nih.gov/pubmed/34725188
http://dx.doi.org/10.1523/JNEUROSCI.2922-20.2021

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