Intrathecal IGF2 siRNA injection provides long-lasting anti-allodynic effect in a spared nerve injury rat model of neuropathic pain

Previous studies have shown an increase of insulin-like growth factor-2 (IGF2) in animal models of neuropathic pain. We aimed to examine the hypothesis that reducing the expression of IGF2 using intrathecal IGF2 small-interfering RNA (siRNA) would attenuate the development of neuropathic pain in rat...

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Detalles Bibliográficos
Autores principales: Chan, Wei-Hung, Huang, Nian-Cih, Lin, Yi-Wen, Lin, Feng-Yen, Tsai, Chien-Sung, Yeh, Chun-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638935/
https://www.ncbi.nlm.nih.gov/pubmed/34855889
http://dx.doi.org/10.1371/journal.pone.0260887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638935/
https://www.ncbi.nlm.nih.gov/pubmed/34855889
http://dx.doi.org/10.1371/journal.pone.0260887

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