Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model

With the increasing availability of large-scale GWAS summary data on various traits, Mendelian randomization (MR) has become commonly used to infer causality between a pair of traits, an exposure and an outcome. It depends on using genetic variants, typically SNPs, as instrumental variables (IVs). T...

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Detalles Bibliográficos
Autores principales: Lin, Zhaotong, Deng, Yangqing, Pan, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639093/
https://www.ncbi.nlm.nih.gov/pubmed/34793444
http://dx.doi.org/10.1371/journal.pgen.1009922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639093/
https://www.ncbi.nlm.nih.gov/pubmed/34793444
http://dx.doi.org/10.1371/journal.pgen.1009922

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