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Combining the strengths of inverse-variance weighting and Egger regression in Mendelian randomization using a mixture of regressions model
With the increasing availability of large-scale GWAS summary data on various traits, Mendelian randomization (MR) has become commonly used to infer causality between a pair of traits, an exposure and an outcome. It depends on using genetic variants, typically SNPs, as instrumental variables (IVs). T...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639093/ https://www.ncbi.nlm.nih.gov/pubmed/34793444 http://dx.doi.org/10.1371/journal.pgen.1009922 |