A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site. A proteome-wide screen revealed photoreceptor cilium actin regulator...

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Detalles Bibliográficos
Autores principales: Hwang, Theresa, Parker, Sara S, Hill, Samantha M, Ilunga, Meucci W, Grant, Robert A, Mouneimne, Ghassan, Keating, Amy E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639148/
https://www.ncbi.nlm.nih.gov/pubmed/34854809
http://dx.doi.org/10.7554/eLife.70601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639148/
https://www.ncbi.nlm.nih.gov/pubmed/34854809
http://dx.doi.org/10.7554/eLife.70601

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