Genetic, cellular, and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

Cell-penetrating peptides (CPPs) allow intracellular delivery of bioactive cargo molecules. The mechanisms allowing CPPs to enter cells are ill-defined. Using a CRISPR/Cas9-based screening, we discovered that KCNQ5, KCNN4, and KCNK5 potassium channels positively modulate cationic CPP direct transloc...

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Detalles Bibliográficos
Autores principales: Trofimenko, Evgeniya, Grasso, Gianvito, Heulot, Mathieu, Chevalier, Nadja, Deriu, Marco A, Dubuis, Gilles, Arribat, Yoan, Serulla, Marc, Michel, Sebastien, Vantomme, Gil, Ory, Florine, Dam, Linh Chi, Puyal, Julien, Amati, Francesca, Lüthi, Anita, Danani, Andrea, Widmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639150/
https://www.ncbi.nlm.nih.gov/pubmed/34713805
http://dx.doi.org/10.7554/eLife.69832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639150/
https://www.ncbi.nlm.nih.gov/pubmed/34713805
http://dx.doi.org/10.7554/eLife.69832

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