Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions after transplantation and during autoimmune disease. To reach sufficient cell yield for treatment, ex vivo isolated autologous or allogenic Tregs need to be expanded exte...

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Detalles Bibliográficos
Autores principales: Ou, Kristy, Hamo, Dania, Schulze, Anne, Roemhild, Andy, Kaiser, Daniel, Gasparoni, Gilles, Salhab, Abdulrahman, Zarrinrad, Ghazaleh, Amini, Leila, Schlickeiser, Stephan, Streitz, Mathias, Walter, Jörn, Volk, Hans-Dieter, Schmueck-Henneresse, Michael, Reinke, Petra, Polansky, Julia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639223/
https://www.ncbi.nlm.nih.gov/pubmed/34869339
http://dx.doi.org/10.3389/fcell.2021.751590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639223/
https://www.ncbi.nlm.nih.gov/pubmed/34869339
http://dx.doi.org/10.3389/fcell.2021.751590

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