Cargando…

Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions after transplantation and during autoimmune disease. To reach sufficient cell yield for treatment, ex vivo isolated autologous or allogenic Tregs need to be expanded exte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ou, Kristy, Hamo, Dania, Schulze, Anne, Roemhild, Andy, Kaiser, Daniel, Gasparoni, Gilles, Salhab, Abdulrahman, Zarrinrad, Ghazaleh, Amini, Leila, Schlickeiser, Stephan, Streitz, Mathias, Walter, Jörn, Volk, Hans-Dieter, Schmueck-Henneresse, Michael, Reinke, Petra, Polansky, Julia K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639223/ https://www.ncbi.nlm.nih.gov/pubmed/34869339 http://dx.doi.org/10.3389/fcell.2021.751590

Ejemplares similares

CRISPR-Cas9-Edited Tacrolimus-Resistant Antiviral T Cells for Advanced Adoptive Immunotherapy in Transplant Recipients
por: Amini, Leila, et al.
Publicado: (2021)

The Value of a Rapid Test of Human Regulatory T Cell Function Needs to be Revised
por: Wendering, Desiree J., et al.
Publicado: (2019)

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype
por: Kressler, Christopher, et al.
Publicado: (2021)

Super-Treg: Toward a New Era of Adoptive Treg Therapy Enabled by Genetic Modifications
por: Amini, Leila, et al.
Publicado: (2021)

Clinical adoptive regulatory T Cell therapy: State of the art, challenges, and prospective
por: Amini, Leila, et al.
Publicado: (2023)

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial
por: Roemhild, Andy, et al.
Publicado: (2020)

Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients
por: Peter, Lena, et al.
Publicado: (2022)

Cyclosporine A but Not Corticosteroids Support Efficacy of Ex Vivo Expanded, Adoptively Transferred Human Tregs in GvHD
por: Landwehr-Kenzel, Sybille, et al.
Publicado: (2021)

Freezing Medium Containing 5% DMSO Enhances the Cell Viability and Recovery Rate After Cryopreservation of Regulatory T Cell Products ex vivo and in vivo
por: Kaiser, Daniel, et al.
Publicado: (2021)

Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients
por: Amini, Leila, et al.
Publicado: (2019)

Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?
por: Wagner, Dimitrios Laurin, et al.
Publicado: (2021)

Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells
por: Glaser, Viktor, et al.
Publicado: (2023)

A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains
por: Salhab, Abdulrahman, et al.
Publicado: (2018)

Functional Surfactants for Molecular Fishing, Capsule Creation, and Single-Cell Gene Expression
por: Chowdhury, Mohammad Suman, et al.
Publicado: (2021)

CAR NK-92 cell–mediated depletion of residual TCR(+) cells for ultrapure allogeneic TCR-deleted CAR T-cell products
por: Kath, Jonas, et al.
Publicado: (2023)

Age‐Associated Changes in Endothelial Transcriptome and Epigenetic Landscapes Correlate With Elevated Risk of Cerebral Microbleeds
por: Mohan, Kshitij, et al.
Publicado: (2023)

Unique and assay specific features of NOMe-, ATAC- and DNase I-seq data
por: Nordström, Karl J V, et al.
Publicado: (2019)

The role of soluble mediators in the clinical course of EBV infection and B cell homeostasis after kidney transplantation
por: Bajda, Sharon, et al.
Publicado: (2020)

DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis
por: Souren, Nicole Y., et al.
Publicado: (2019)

Human IgA-Expressing Bone Marrow Plasma Cells Characteristically Upregulate Programmed Cell Death Protein-1 Upon B Cell Receptor Stimulation
por: Wiedemann, Annika, et al.
Publicado: (2021)

Batch Effects during Human Bone Marrow Stromal Cell Propagation Prevail Donor Variation and Culture Duration: Impact on Genotype, Phenotype and Function
por: Brachtl, Gabriele, et al.
Publicado: (2022)

Standardized assay for assessment of minimal residual disease in blood, bone marrow and apheresis from patients with plasma cell myeloma
por: Blum, Agnieszka, et al.
Publicado: (2019)

Transcriptional and Epigenetic Consequences of DMSO Treatment on HepaRG Cells
por: Dubois-Pot-Schneider, Hélène, et al.
Publicado: (2022)

HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients
por: Steiner, Sophie, et al.
Publicado: (2020)

Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells
por: Kath, Jonas, et al.
Publicado: (2022)

reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells
por: Kinkley, Sarah, et al.
Publicado: (2016)

Strong priming of T cells adoptively transferred into scid mice
Publicado: (1991)

The TreaT-Assay: A Novel Urine-Derived Donor Kidney Cell-Based Assay for Prediction of Kidney Transplantation Outcome
por: Thieme, Constantin J., et al.
Publicado: (2019)

Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study
por: Streitz, Mathias, et al.
Publicado: (2013)

Killer-like receptors and GPR56 progressive expression defines cytokine production of human CD4(+) memory T cells
por: Truong, Kim-Long, et al.
Publicado: (2019)

Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells
por: Drzeniek, Norman M, et al.
Publicado: (2021)

A Monoclonal Human Alveolar Epithelial Cell Line (“Arlo”) with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections
por: Carius, Patrick, et al.
Publicado: (2023)

Video recording of neonatal resuscitation: A feasibility study to inform widespread adoption
por: Shivananda, Sandesh, et al.
Publicado: (2017)

Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy
por: Sharma, Sandhya, et al.
Publicado: (2023)

WHO Air Quality Guidelines Need to be Adopted
por: Amini, Heresh
Publicado: (2021)

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties
por: Andrzejewska, Anastazja, et al.
Publicado: (2019)

“What Makes Us Strong?”: Dyadic Coping in Italian Prospective Adoptive Couples
por: Canzi, Elena, et al.
Publicado: (2019)

To be, or not to be immunocompetent
por: Volk, Hans-Dieter, et al.
Publicado: (2013)

Long-Term Signs of T Cell and Myeloid Cell Activation After Intestinal Transplantation With Cellular Rejections Contributing to Further Increase of CD16(+) Cell Subsets
por: Stobutzki, Nadja, et al.
Publicado: (2019)

Evolutionary ecology meets the antibiotic crisis: Can we control pathogen adaptation through sequential therapy?
por: Roemhild, Roderich, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_o5t2t2fs45rrkbogit400o6d09