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A rapidly reversible mutation generates subclonal genetic diversity and unstable drug resistance

Most genetic changes have negligible reversion rates. As most mutations that confer resistance to an adverse condition (e.g., drug treatment) also confer a growth defect in its absence, it is challenging for cells to genetically adapt to transient environmental changes. Here, we identify a set of ra...

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Detalles Bibliográficos
Autores principales: Dan, Lufeng, Li, Yuze, Chen, Shuhua, Liu, Jingbo, Wang, Yu, Li, Fangting, He, Xiangwei, Carey, Lucas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639346/
https://www.ncbi.nlm.nih.gov/pubmed/34675074
http://dx.doi.org/10.1073/pnas.2019060118