Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice

Self-amplifying RNA replicons are promising platforms for vaccine generation. Their defects in one or more essential functions for viral replication, particle assembly, or dissemination make them highly safe as vaccines. We previously showed that the deletion of the envelope (E) gene from the Middle...

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Detalles Bibliográficos
Autores principales: Gutiérrez-Álvarez, J., Honrubia, J. M., Sanz-Bravo, A., González-Miranda, E., Fernández-Delgado, R., Rejas, M. T., Zúñiga, S., Sola, I., Enjuanes, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639359/
https://www.ncbi.nlm.nih.gov/pubmed/34686605
http://dx.doi.org/10.1073/pnas.2111075118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639359/
https://www.ncbi.nlm.nih.gov/pubmed/34686605
http://dx.doi.org/10.1073/pnas.2111075118

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