Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency

Energy production via the mitochondrial electron transport chain (ETC) and mitophagy are two important processes affected in Parkinson’s disease (PD). Interestingly, PINK1, mutations of which cause early-onset PD, plays a key role in both processes, suggesting that these two mechanisms are connected...

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Detalles Bibliográficos
Autores principales: Vos, Melissa, Dulovic-Mahlow, Marija, Mandik, Frida, Frese, Lisa, Kanana, Yuliia, Haissatou Diaw, Sokhna, Depperschmidt, Julia, Böhm, Claudia, Rohr, Jonas, Lohnau, Thora, König, Inke R., Klein, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639384/
https://www.ncbi.nlm.nih.gov/pubmed/34686591
http://dx.doi.org/10.1073/pnas.2025347118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639384/
https://www.ncbi.nlm.nih.gov/pubmed/34686591
http://dx.doi.org/10.1073/pnas.2025347118

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