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Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustiv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639431/ https://www.ncbi.nlm.nih.gov/pubmed/34901827 http://dx.doi.org/10.1016/j.fochx.2021.100171 |
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author | Silva, Amélia M. Félix, Luís M. Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J. Bunzel, Mirko Nunes, Fernando M. |
author_facet | Silva, Amélia M. Félix, Luís M. Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J. Bunzel, Mirko Nunes, Fernando M. |
author_sort | Silva, Amélia M. |
collection | PubMed |
description | Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries. |
format | Online Article Text |
id | pubmed-8639431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-86394312021-12-09 Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits Silva, Amélia M. Félix, Luís M. Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J. Bunzel, Mirko Nunes, Fernando M. Food Chem X Research Article Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries. Elsevier 2021-11-25 /pmc/articles/PMC8639431/ /pubmed/34901827 http://dx.doi.org/10.1016/j.fochx.2021.100171 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Silva, Amélia M. Félix, Luís M. Teixeira, Isabel Martins-Gomes, Carlos Schäfer, Judith Souto, Eliana B. Santos, Dario J. Bunzel, Mirko Nunes, Fernando M. Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title | Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_full | Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_fullStr | Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_full_unstemmed | Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_short | Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
title_sort | orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639431/ https://www.ncbi.nlm.nih.gov/pubmed/34901827 http://dx.doi.org/10.1016/j.fochx.2021.100171 |
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