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Unravelling roles of error-prone DNA polymerases in shaping cancer genomes

Mutagenesis is a key hallmark and enabling characteristic of cancer cells, yet the diverse underlying mutagenic mechanisms that shape cancer genomes are not understood. This review will consider the emerging challenge of determining how DNA damage response pathways—both tolerance and repair—act upon...

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Detalles Bibliográficos
Autores principales: Vaziri, Cyrus, Rogozin, Igor B., Gu, Qisheng, Wu, Di, Day, Tovah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639439/
https://www.ncbi.nlm.nih.gov/pubmed/34663880
http://dx.doi.org/10.1038/s41388-021-02032-9