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Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration

Alterations in cholesterol metabolism in the brain have a major role in the physiology of Alzheimer’s disease (AD). Oxysterols are cholesterol metabolites with multiple implications in memory functions and in neurodegeneration. Previous studies have shown detrimental effects of cholesterol metabolit...

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Detalles Bibliográficos
Autores principales: Loera-Valencia, Raúl, Ismail, Muhammad-Al-Mustafa, Goikolea, Julen, Lodeiro, Maria, Mateos, Laura, Björkhem, Ingemar, Puerta, Elena, Romão, Mariana A., Gomes, Cláudio M., Merino-Serrais, Paula, Maioli, Silvia, Cedazo-Minguez, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639576/
https://www.ncbi.nlm.nih.gov/pubmed/34449045
http://dx.doi.org/10.1007/s12035-021-02521-8