Cargando…
Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies
The β-amyloid peptide (Aβ) is found as amyloid fibrils in senile plaques, a typical hallmark of Alzheimer’s disease (AD). However, intermediate soluble oligomers of Aβ are now recognized as initiators of the pathogenic cascade leading to AD. Studies using recombinant Aβ have shown that hexameric Aβ...
Autores principales: | Vrancx, Céline, Vadukul, Devkee M., Suelves, Nuria, Contino, Sabrina, D’Auria, Ludovic, Perrin, Florian, van Pesch, Vincent, Hanseeuw, Bernard, Quinton, Loïc, Kienlen-Campard, Pascal |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639606/ https://www.ncbi.nlm.nih.gov/pubmed/34608607 http://dx.doi.org/10.1007/s12035-021-02567-8 |
Ejemplares similares
-
An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β
por: Vadukul, Devkee M., et al.
Publicado: (2021) -
Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates
por: Papadopoulos, Nicolas, et al.
Publicado: (2022) -
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
por: Contino, Sabrina, et al.
Publicado: (2021) -
Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
por: Perrin, Florian, et al.
Publicado: (2021) -
Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization
por: Perrin, Florian, et al.
Publicado: (2020)