Replica exchange molecular dynamics simulations reveal self-association sites in M-crystallin caused by mutations provide insights of cataract

Crystallins are ubiquitous, however, prevalence is seen in eye lens. Eye lens crystallins are long-lived and structural intactness is required for maintaining lens transparency and protein solubility. Mutations in crystallins often lead to cataract. In this study, we performed mutations at specific...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Sunita, Hosur, Ramakrishna V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639718/
https://www.ncbi.nlm.nih.gov/pubmed/34857812
http://dx.doi.org/10.1038/s41598-021-02728-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639718/
https://www.ncbi.nlm.nih.gov/pubmed/34857812
http://dx.doi.org/10.1038/s41598-021-02728-8

Ejemplares similares