Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the blastocyst, implicating alternative repressive pathways before implantation. Indeed, in embryonic stem cells (ESCs), an overlapping set of gen...

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Detalles Bibliográficos
Autores principales: Mochizuki, Kentaro, Sharif, Jafar, Shirane, Kenjiro, Uranishi, Kousuke, Bogutz, Aaron B., Janssen, Sanne M., Suzuki, Ayumu, Okuda, Akihiko, Koseki, Haruhiko, Lorincz, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639735/
https://www.ncbi.nlm.nih.gov/pubmed/34857746
http://dx.doi.org/10.1038/s41467-021-27345-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639735/
https://www.ncbi.nlm.nih.gov/pubmed/34857746
http://dx.doi.org/10.1038/s41467-021-27345-x

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