Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity

Lassa virus is endemic in West Africa and can cause severe hemorrhagic fever. The viral L protein transcribes and replicates the RNA genome via its RNA-dependent RNA polymerase activity. Here, we present nine cryo-EM structures of the L protein in the apo-, promoter-bound pre-initiation and active R...

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Detalles Bibliográficos
Autores principales: Kouba, Tomas, Vogel, Dominik, Thorkelsson, Sigurdur R., Quemin, Emmanuelle R. J., Williams, Harry M., Milewski, Morlin, Busch, Carola, Günther, Stephan, Grünewald, Kay, Rosenthal, Maria, Cusack, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639829/
https://www.ncbi.nlm.nih.gov/pubmed/34857749
http://dx.doi.org/10.1038/s41467-021-27305-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639829/
https://www.ncbi.nlm.nih.gov/pubmed/34857749
http://dx.doi.org/10.1038/s41467-021-27305-5

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