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KSHV transactivator-derived small peptide traps coactivators to attenuate MYC and inhibits leukemia and lymphoma cell growth

In herpesvirus replicating cells, host cell gene transcription is frequently down-regulated because important transcriptional apparatuses are appropriated by viral transcription factors. Here, we show a small peptide derived from the Kaposi’s sarcoma-associated herpesvirus transactivator (K-Rta) seq...

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Detalles Bibliográficos
Autores principales: Shimoda, Michiko, Lyu, Yuanzhi, Wang, Kang-Hsin, Kumar, Ashish, Miura, Hiroki, Meckler, Joshua F., Davis, Ryan R., Chantarasrivong, Chanikarn, Izumiya, Chie, Tepper, Clifford G., Nakajima, Ken-ichi, Tuscano, Joseph, Barisone, Gustavo, Izumiya, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8639922/
https://www.ncbi.nlm.nih.gov/pubmed/34857874
http://dx.doi.org/10.1038/s42003-021-02853-0