Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery

To optimize gene delivery to myelinating Schwann cells we compared clinically relevant AAV serotypes and injection routes. AAV9 and AAVrh10 vectors expressing either EGFP or the neuropathy-associated gene GJB1/Connexin32 (Cx32) under a myelin specific promoter were injected intrathecally or intraven...

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Detalles Bibliográficos
Autores principales: Kagiava, A., Richter, J., Tryfonos, C., Leal-Julià, M., Sargiannidou, I., Christodoulou, C., Bosch, A., Kleopa, K. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640002/
https://www.ncbi.nlm.nih.gov/pubmed/34857831
http://dx.doi.org/10.1038/s41598-021-02694-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640002/
https://www.ncbi.nlm.nih.gov/pubmed/34857831
http://dx.doi.org/10.1038/s41598-021-02694-1

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