ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function

Proteostasis is a challenge for cellular organisms, as all known protein synthesis machineries are error-prone. Here we show by cell fractionation and microscopy studies that misfolded proteins formed in the endoplasmic reticulum can become associated with and partly transported into mitochondria, r...

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Detalles Bibliográficos
Autores principales: Cortés Sanchón, Adrián, Santhosh Kumar, Harshitha, Mantovani, Matilde, Osinnii, Ivan, Mateos, José María, Kaech, Andres, Shcherbakov, Dimitri, Akbergenov, Rashid, Böttger, Erik C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640021/
https://www.ncbi.nlm.nih.gov/pubmed/34857875
http://dx.doi.org/10.1038/s42003-021-02873-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640021/
https://www.ncbi.nlm.nih.gov/pubmed/34857875
http://dx.doi.org/10.1038/s42003-021-02873-w

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