Dynamically Accumulating Homologous Recombination Deficiency Score Served as an Important Prognosis Factor in High-Grade Serous Ovarian Cancer

Background: The homologous recombination (HR) pathway defects in cancers induced abrogation of cell cycle checkpoints, resulting in the accumulation of DNA damage, mitotic catastrophe, and cell death. Cancers with BRCA1/2 loss and other accumulation of similar genomic scars resulting in HRD displaye...

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Detalles Bibliográficos
Autores principales: Su, Rongjia, Liu, Yuan, Wu, Xiaomei, Xiang, Jiangdong, Xi, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640082/
https://www.ncbi.nlm.nih.gov/pubmed/34869593
http://dx.doi.org/10.3389/fmolb.2021.762741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640082/
https://www.ncbi.nlm.nih.gov/pubmed/34869593
http://dx.doi.org/10.3389/fmolb.2021.762741

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