Replacement of heme by soluble guanylate cyclase (sGC) activators abolishes heme-nitric oxide/oxygen (H-NOX) domain structural plasticity

The gasotransmitter nitric oxide (NO) is a critical endogenous regulator of homeostasis, in major part via the generation of cGMP (cyclic guanosine monophosphate) from GTP (guanosine triphosphate) by NO's main physiological receptor, the soluble guanylate cyclase (sGC). sGC is a heterodimer, co...

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Detalles Bibliográficos
Autores principales: Argyriou, Aikaterini I., Makrynitsa, Garyfallia I., Dalkas, Georgios, Georgopoulou, Dimitra A., Salagiannis, Konstantinos, Vazoura, Vassiliki, Papapetropoulos, Andreas, Topouzis, Stavros, Spyroulias, Georgios A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640258/
https://www.ncbi.nlm.nih.gov/pubmed/34901882
http://dx.doi.org/10.1016/j.crstbi.2021.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640258/
https://www.ncbi.nlm.nih.gov/pubmed/34901882
http://dx.doi.org/10.1016/j.crstbi.2021.11.003

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