N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate

Huntington’s disease (HD) is a neurodegenerative disorder caused by a poly-CAG expansion in the first exon of the HTT gene, resulting in an extended poly-glutamine tract in the N-terminal domain of the Huntingtin (Htt) protein product. Proteolytic fragments of the poly-glutamine–containing N-termina...

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Detalles Bibliográficos
Autores principales: Gottlieb, Leah, Guo, Lin, Shorter, James, Marmorstein, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640455/
https://www.ncbi.nlm.nih.gov/pubmed/34732320
http://dx.doi.org/10.1016/j.jbc.2021.101363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640455/
https://www.ncbi.nlm.nih.gov/pubmed/34732320
http://dx.doi.org/10.1016/j.jbc.2021.101363

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