Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites

Common fragile sites (CFSs) are difficult-to-replicate genomic regions that form gaps and breaks on metaphase chromosomes under replication stress. They are hotspots for chromosomal instability in cancer. Repetitive sequences located at CFS loci are inefficiently copied by replicative DNA polymerase...

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Detalles Bibliográficos
Autores principales: Twayana, Shyam, Bacolla, Albino, Barreto-Galvez, Angelica, De-Paula, Ruth B., Drosopoulos, William C., Kosiyatrakul, Settapong T., Bouhassira, Eric E., Tainer, John A., Madireddy, Advaitha, Schildkraut, Carl L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640788/
https://www.ncbi.nlm.nih.gov/pubmed/34815340
http://dx.doi.org/10.1073/pnas.2106477118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640788/
https://www.ncbi.nlm.nih.gov/pubmed/34815340
http://dx.doi.org/10.1073/pnas.2106477118

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