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Translesion polymerase eta both facilitates DNA replication and promotes increased human genetic variation at common fragile sites
Common fragile sites (CFSs) are difficult-to-replicate genomic regions that form gaps and breaks on metaphase chromosomes under replication stress. They are hotspots for chromosomal instability in cancer. Repetitive sequences located at CFS loci are inefficiently copied by replicative DNA polymerase...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640788/ https://www.ncbi.nlm.nih.gov/pubmed/34815340 http://dx.doi.org/10.1073/pnas.2106477118 |