PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness

The cystine-glutamate antiporter, xCT, supports a glutathione synthesis program enabling cancer cells to cope with metabolically stressful microenvironments. Up-regulated xCT, in combination with glutaminolysis, leads to increased extracellular glutamate, which promotes invasive behavior by activati...

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Detalles Bibliográficos
Autores principales: Rabas, Nicolas, Palmer, Sarah, Mitchell, Louise, Ismail, Shehab, Gohlke, Andrea, Riley, Joel S., Tait, Stephen W.G., Gammage, Payam, Soares, Leandro Lemgruber, Macpherson, Iain R., Norman, Jim C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641410/
https://www.ncbi.nlm.nih.gov/pubmed/34623384
http://dx.doi.org/10.1083/jcb.202006049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641410/
https://www.ncbi.nlm.nih.gov/pubmed/34623384
http://dx.doi.org/10.1083/jcb.202006049

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