Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells

Rationale: SARS-CoV-2 gains entrance to airway epithelial cells (AECs) through binding of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. However, ACE2 also converts angiotensin II into angiotensin-(1-7) and counterbalances the renin-angiotensin-aldosterone...

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Detalles Bibliográficos
Autores principales: Okoloko, Oghenemega, Vanderwall, Elizabeth R., Rich, Lucille M., White, Maria P., Reeves, Stephen R., Harrington, Whitney E., Barrow, Kaitlyn A., Debley, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641911/
https://www.ncbi.nlm.nih.gov/pubmed/34867390
http://dx.doi.org/10.3389/fphar.2021.765951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641911/
https://www.ncbi.nlm.nih.gov/pubmed/34867390
http://dx.doi.org/10.3389/fphar.2021.765951

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