PLK1 regulates the PrimPol damage tolerance pathway during the cell cycle

Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways allow lesion bypass to ensure efficient genome duplication. One such pathway is repriming, mediated by Primase-Polymerase (PrimPol) in human cells. However, the mechanisms...

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Detalles Bibliográficos
Autores principales: Bailey, Laura J., Teague, Rebecca, Kolesar, Peter, Bainbridge, Lewis J., Lindsay, Howard D., Doherty, Aidan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641930/
https://www.ncbi.nlm.nih.gov/pubmed/34860556
http://dx.doi.org/10.1126/sciadv.abh1004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641930/
https://www.ncbi.nlm.nih.gov/pubmed/34860556
http://dx.doi.org/10.1126/sciadv.abh1004

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