Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

Dysregulation of tumor-relevant proteins may contribute to human hepatocellular carcinoma (HCC) tumorigenesis. FBXO45 is an E3 ubiquitin ligase that is frequently elevated expression in human HCC. However, it remains unknown whether FBXO45 is associated with hepatocarcinogenesis and how to treat HCC...

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Detalles Bibliográficos
Autores principales: Lin, Xiao-Tong, Yu, Hong-Qiang, Fang, Lei, Tan, Ye, Liu, Ze-Yu, Wu, Di, Zhang, Jie, Xiong, Hao-Jun, Xie, Chuan-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641947/
https://www.ncbi.nlm.nih.gov/pubmed/34779401
http://dx.doi.org/10.7554/eLife.70715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641947/
https://www.ncbi.nlm.nih.gov/pubmed/34779401
http://dx.doi.org/10.7554/eLife.70715

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