Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K(2) subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum (ER)-associated degradation (ERAD) of HMG C...

Descripción completa

Detalles Bibliográficos
Autores principales: Elsabrouty, Rania, Jo, Youngah, Hwang, Seonghwan, Jun, Dong-Jae, DeBose-Boyd, Russell A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641950/
https://www.ncbi.nlm.nih.gov/pubmed/34842525
http://dx.doi.org/10.7554/eLife.64688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641950/
https://www.ncbi.nlm.nih.gov/pubmed/34842525
http://dx.doi.org/10.7554/eLife.64688

Ejemplares similares