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Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K(2) subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum (ER)-associated degradation (ERAD) of HMG C...

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Detalles Bibliográficos
Autores principales:	Elsabrouty, Rania, Jo, Youngah, Hwang, Seonghwan, Jun, Dong-Jae, DeBose-Boyd, Russell A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8641950/ https://www.ncbi.nlm.nih.gov/pubmed/34842525 http://dx.doi.org/10.7554/eLife.64688

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