BET protein degradation triggers DR5-mediated immunogenic cell death to suppress colorectal cancer and potentiate immune checkpoint blockade

Bromodomain and Extra-Terminal domain (BET) family proteins are epigenetic readers that play a critical role in oncogenesis by controlling the expression of oncogenes such as c-Myc. Targeting BET family proteins has recently emerged as a promising anticancer strategy. However, the molecular mechanis...

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Detalles Bibliográficos
Autores principales: Tong, Jingshan, Tan, Xiao, Risnik, Denise, Gao, Man, Song, Xiangping, Ermine, Kaylee, Shen, Liangfang, Wang, Shaomeng, Yu, Jian, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642302/
https://www.ncbi.nlm.nih.gov/pubmed/34615996
http://dx.doi.org/10.1038/s41388-021-02041-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642302/
https://www.ncbi.nlm.nih.gov/pubmed/34615996
http://dx.doi.org/10.1038/s41388-021-02041-8

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