Find and cut-and-transfer (FiCAT) mammalian genome engineering

While multiple technologies for small allele genome editing exist, robust technologies for targeted integration of large DNA fragments in mammalian genomes are still missing. Here we develop a gene delivery tool (FiCAT) combining the precision of a CRISPR-Cas9 (find module), and the payload transfer...

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Detalles Bibliográficos
Autores principales: Pallarès-Masmitjà, Maria, Ivančić, Dimitrije, Mir-Pedrol, Júlia, Jaraba-Wallace, Jessica, Tagliani, Tommaso, Oliva, Baldomero, Rahmeh, Amal, Sánchez-Mejías, Avencia, Güell, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642419/
https://www.ncbi.nlm.nih.gov/pubmed/34862378
http://dx.doi.org/10.1038/s41467-021-27183-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642419/
https://www.ncbi.nlm.nih.gov/pubmed/34862378
http://dx.doi.org/10.1038/s41467-021-27183-x

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