Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

Given the opposing effects of Akt and AMP-activated protein kinase (AMPK) on metabolic homeostasis, this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis. Akt2–Ampkα2 double knockout (DKO) mice were placed on high fat diet for 5 months. Glucose metaboli...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shuyi, Tao, Jun, Chen, Huaguo, Kandadi, Machender R., Sun, Mingming, Xu, Haixia, Lopaschuk, Gary D., Lu, Yan, Zheng, Junmeng, Peng, Hu, Ren, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642450/
https://www.ncbi.nlm.nih.gov/pubmed/34900533
http://dx.doi.org/10.1016/j.apsb.2021.07.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642450/
https://www.ncbi.nlm.nih.gov/pubmed/34900533
http://dx.doi.org/10.1016/j.apsb.2021.07.006

Ejemplares similares