Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ)

In response to genotoxic stress, the tumor suppressor p53 acts as a transcription factor by regulating the expression of genes critical for cancer prevention. Mutations in the gene encoding p53 are associated with cancer development. PRIMA-1 and eprenetapopt (APR-246/PRIMA-1(MET)) are small molecule...

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Detalles Bibliográficos
Autores principales: Degtjarik, Oksana, Golovenko, Dmitrij, Diskin-Posner, Yael, Abrahmsén, Lars, Rozenberg, Haim, Shakked, Zippora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642532/
https://www.ncbi.nlm.nih.gov/pubmed/34862374
http://dx.doi.org/10.1038/s41467-021-27142-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642532/
https://www.ncbi.nlm.nih.gov/pubmed/34862374
http://dx.doi.org/10.1038/s41467-021-27142-6

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