RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis

Receptor-interacting protein kinase 1 (RIPK1) is a key regulator of inflammation and cell death. Many sites on RIPK1, including serine 25, are phosphorylated to inhibit its kinase activity and cell death. How these inhibitory phosphorylation sites are dephosphorylated is poorly understood. Using a s...

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Detalles Bibliográficos
Autores principales: Du, Jingchun, Xiang, Yougui, Liu, Hua, Liu, Shuzhen, Kumar, Ashwani, Xing, Chao, Wang, Zhigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642546/
https://www.ncbi.nlm.nih.gov/pubmed/34862394
http://dx.doi.org/10.1038/s41467-021-27367-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642546/
https://www.ncbi.nlm.nih.gov/pubmed/34862394
http://dx.doi.org/10.1038/s41467-021-27367-5

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