Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis

Amino acid availability is sensed by various signaling molecules, including general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). However, it is unclear how these sensors are associated with cancer cell survival under low amino acid availability. In the pr...

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Detalles Bibliográficos
Autores principales: Jin, Hyeon-Ok, Hong, Sung-Eun, Kim, Ji-Young, Jang, Se-Kyeong, Park, In-Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642548/
https://www.ncbi.nlm.nih.gov/pubmed/34862383
http://dx.doi.org/10.1038/s41419-021-04417-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642548/
https://www.ncbi.nlm.nih.gov/pubmed/34862383
http://dx.doi.org/10.1038/s41419-021-04417-w

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