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Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axis
Amino acid availability is sensed by various signaling molecules, including general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). However, it is unclear how these sensors are associated with cancer cell survival under low amino acid availability. In the pr...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642548/ https://www.ncbi.nlm.nih.gov/pubmed/34862383 http://dx.doi.org/10.1038/s41419-021-04417-w |